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This paper presents the Learning the Universe Implicit Likelihood Inference (LtU-ILI) pipeline, a codebase for rapid, user-friendly, and cutting-edge machine learning (ML) inference in astrophysics and cosmology. The pipeline includes software for implementing various neural architectures, training schema, priors, and density estimators in a manner easily adaptable to any research workflow. It includes comprehensive validation metrics to assess posterior estimate coverage, enhancing the reliability of inferred results. Additionally, the pipeline is easily parallelizable, designed for efficient exploration of modeling hyperparameters. To demonstrate its capabilities, we present real applications across a range of astrophysics and cosmology problems, such as: estimating galaxy cluster masses from X-ray photometry; inferring cosmology from matter power spectra and halo point clouds; characterising progenitors in gravitational wave signals; capturing physical dust parameters from galaxy colors and luminosities; and establishing properties of semi-analytic models of galaxy formation. We also include exhaustive benchmarking and comparisons of all implemented methods as well as discussions about the challenges and pitfalls of ML inference in astronomical sciences. All code and examples are made publicly available at https://github.com/maho3/ltu-ili. 

Abstract Galaxies can be characterized by many internal properties such as stellar mass, gas metallicity, and star formation rate. We quantify the amount of cosmological and astrophysical information that the internal properties of individual galaxies and their host dark matter halos contain. We train neural networks using hundreds of thousands of galaxies from 2000 state-of-the-art hydrodynamic simulations with different cosmologies and astrophysical models of the CAMELS project to perform likelihood-free inference on the value of the cosmological and astrophysical parameters. We find that knowing the internal properties of a single galaxy allows our models to infer the value of Ω m , at fixed Ω b , with a ∼10% precision, while no constraint can be placed on σ 8 . Our results hold for any type of galaxy, central or satellite, massive or dwarf, at all considered redshifts, z ≤ 3, and they incorporate uncertainties in astrophysics as modeled in CAMELS. However, our models are not robust to changes in subgrid physics due to the large intrinsic differences the two considered models imprint on galaxy properties. We find that the stellar mass, stellar metallicity, and maximum circular velocity are among the most important galaxy properties to determine the value of Ω m . We believe that our results can be explained by considering that changes in the value of Ω m , or potentially Ω b /Ω m , affect the dark matter content of galaxies, which leaves a signature in galaxy properties distinct from the one induced by galactic processes. Our results suggest that the low-dimensional manifold hosting galaxy properties provides a tight direct link between cosmology and astrophysics.